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HomeAbout AboutWhy PENBRAYA?Risks of Meningococcal DiseaseGaps in Vaccination CoverageDosing & Recommendations Effectiveness & Safety Effectiveness
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ACIP RecommendationIn October 2023, the Advisory Committee on Immunization Practices (ACIP) voted on meningococcal vaccination recommendations that are official and have been adopted by the CDC.1 They have been published in MMWR. Click here for more details.1*TitleExample TextPENBRAYA® is the FIRST pentavalent (5-in-1) MenABCWY vaccine1-3Now you can offer broad protection against the 5 leading meningococcal serogroups (A, B, C, W, and Y) with one less injection1,2,4-10*†
Vaccinate your healthy 16-year-old patients with 5-in-1 PENBRAYA1,2
Based on data in the CDC-enhanced meningococcal surveillance reports from 2017 to 2022 for 16- to 23-year-olds. The number of cases for each serogroup were as follows: MenA=0; MenB=120; MenC=20; MenW=5; MenY=9; other/unknown=31; and non-groupable=49.4-9One less injection is needed for healthy adolescents at age 16 to complete the recommended meningococcal vaccination schedule compared to separate MenACWY and MenB vaccines.1CDC=Centers for Disease Control and Prevention; MMWR=Morbidity and Mortality Weekly Report.Helpful information about getting started with PENBRAYA Why PENBRAYA?

PENBRAYA offers broad protection against the 5 leading meningococcal serogroups (A, B, C, W, and Y) in a combination vaccine

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Learn about ACIP-recommended dosing for PENBRAYA

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PENBRAYA can streamline vaccination for your patients and practice 

LoadingMeningococcal disease in the newsCDC Health Alert—Increase in Serogroup Y Meningococcal Disease Cases in the United States11

The CDC had issued a health advisory to alert healthcare providers to an increase in serogroup Y meningococcal disease.

The CDC had issued a health advisory to alert healthcare providers to an increase in serogroup Y meningococcal disease.

Distributed via the CDC Health Alert Network
March 28, 2024, 1:30 PM ETDistributed via the CDC Health Alert Network March 28, 2024, 1:30 PM ETStatewide Serogroup Y Outbreak in Virginia12

The Virginia Department of Health responded to a statewide outbreak of meningococcal disease caused by the bacterium Neisseria meningitidis serogroup Y. 
 

The Virginia Department of Health responded to a statewide outbreak of meningococcal disease caused by the bacterium Neisseria meningitidis serogroup Y. 

Distributed by Virginia Department of Health
Last updated April 2, 2024Distributed by Virginia Department of Health Last updated April 2, 2024References: 1. Collins JP, Crowe SJ, Ortega-Sanchez IR, et al. Use of the Pfizer pentavalent meningococcal vaccine among persons aged ≥10 years: recommendations of the Advisory Committee on Immunization Practices — United States, 2023. MMWR Morb Mortal Wkly Rep. 2024;73(15):345-350. 2. PENBRAYA® (Meningococcal Groups A, B, C, W, and Y Vaccine). Prescribing information. Pfizer Inc.; 2024. 3. Centers for Disease Control and Prevention. Meningococcal disease: meningococcal vaccination. Updated June 26, 2024. Accessed January 13, 2025. https://www.cdc.gov/meningococcal/vaccines/index.html 4. Centers for Disease Control and Prevention. Enhanced meningococcal disease surveillance report, 2017: confirmed and probable cases reported to the National Notifiable Diseases Surveillance System, 2017. Published October 7, 2019. Accessed February 3, 2025. https://stacks.cdc.gov/view/cdc/140464 5. Centers for Disease Control and Prevention. Enhanced meningococcal disease surveillance report, 2018: confirmed and probable cases reported to the National Notifiable Diseases Surveillance System, 2018. Published October 7, 2019. Accessed February 3, 2025. https://stacks.cdc.gov/view/cdc/111348 6. Centers for Disease Control and Prevention. Enhanced meningococcal disease surveillance report, 2019: confirmed and probable cases reported to the National Notifiable Diseases Surveillance System, 2019. Updated May 11, 2023. Accessed February 3, 2025. https://www.cdc.gov/meningococcal/downloads/ncird-ems-report-2019.pdf 7. Centers for Disease Control and Prevention. Enhanced meningococcal disease surveillance report, 2020: confirmed and probable cases reported to the National Notifiable Diseases Surveillance System, 2020. Updated May 11, 2023. Accessed February 3, 2025. https://www.cdc.gov/meningococcal/downloads/ncird-ems-report-2020.pdf 8. Centers for Disease Control and Prevention. Enhanced meningococcal disease surveillance report, 2021: confirmed and probable cases reported to the National Notifiable Diseases Surveillance System, 2021. Updated June 21, 2023. Accessed February 3, 2025. https://www.cdc.gov/meningococcal/downloads/ncird-ems-report-2021.pdf 9. Centers for Disease Control and Prevention. Enhanced meningococcal disease surveillance report, 2022: confirmed and probable cases reported to the National Notifiable Diseases Surveillance System, 2022. Updated April 8, 2024. Accessed February 3, 2025. https://www.cdc.gov/meningococcal/downloads/ncird-ems-Report-2022-508.pdf 10. Pingali C, Yankey D, Chen M, et al. National vaccination coverage among adolescents aged 13-17 years—National Immunization Survey–Teen, United States, 2023. MMWR Morb Mortal Wkly Rep. 2024;73(33):708-714. 11. Centers for Disease Control and Prevention. Health Alert Network (HAN). Increase in invasive serogroup Y meningococcal disease in the United States. Published March 28, 2024. Accessed January 13, 2025. https://emergency.cdc.gov/han/2024/han00505.asp 12. Surveillance and investigation: meningococcal disease outbreak response. Virginia Department of Health. Last reviewed February 25, 2025. Accessed March 28, 2025. https://www.vdh.virginia.gov/surveillance-and-investigation/meningococcal-disease-outbreak-response

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Indications
  • PENBRAYA is indicated for active immunization to prevent invasive disease caused by Neisseria meningitidis serogroups A, B, C, W, and Y. PENBRAYA is approved for use in individuals 10 through 25 years of age
  • TRUMENBA is indicated for active immunization to prevent invasive disease caused by Neisseria meningitidis serogroup B. TRUMENBA is approved for use in individuals 10 through 25 years of age 
Important Safety Information
  • Do not administer PENBRAYA or TRUMENBA to individuals with a history of severe allergic reaction (eg, anaphylaxis) to any component of PENBRAYA or TRUMENBA. Appropriate medical treatment used to manage allergic reactions must be available in the event an anaphylactic reaction occurs immediately following administration of PENBRAYA or TRUMENBA
  • Syncope (fainting) may occur in association with administration of injectable vaccines, including PENBRAYA or TRUMENBA. Procedures should be in place to avoid injury from fainting
  • Some individuals with altered immunocompetence may have reduced immune responses to PENBRAYA or TRUMENBA
  • Individuals with certain complement deficiencies and individuals receiving treatment that inhibits terminal complement activation are at increased risk for invasive disease caused by N. meningitidis groups A, B, C, W, and Y, even if they develop antibodies following vaccination with PENBRAYA
  • Individuals with certain complement deficiencies and individuals receiving treatment that inhibits terminal complement activation are at increased risk for invasive disease caused by N. meningitidis group B, even if they develop antibodies following vaccination with TRUMENBA
  • Vaccination with PENBRAYA or TRUMENBA may not protect all vaccine recipients
  • Vaccination with PENBRAYA does not substitute for vaccination with a tetanus toxoid–containing vaccine to prevent tetanus
  • Guillain-Barré syndrome (GBS) has been reported in temporal relationship following administration of another US-licensed meningococcal quadrivalent polysaccharide conjugate vaccine. The decision by the healthcare professional to administer PENBRAYA to individuals with a history of GBS should take into account the expected benefits and potential risks 
  • For PENBRAYA, the most commonly reported (≥15%) solicited adverse reactions after Dose 1 and Dose 2, respectively, were pain at the injection site (89% and 84%), fatigue (52% and 48%), headache (47% and 40%), muscle pain (26% and 23%), injection site redness (26% and 23%), injection site swelling (25% and 24%), joint pain (20% and 18%), and chills (20% and 16%)
  • For TRUMENBA, the most common solicited adverse reactions in adolescents and young adults were pain at injection site (≥85%), fatigue (≥60%), headache (≥55%), and muscle pain (≥35%)
  • Data are not available on the safety and effectiveness of using TRUMENBA and other meningococcal group B vaccines interchangeably to complete the vaccination series
  • The safety and effectiveness of PENBRAYA or TRUMENBA have not been established in pregnant individuals
     
Patients should always ask their healthcare providers for medical advice about adverse events. You are encouraged to report negative side effects of vaccines to the US Food and Drug Administration (FDA) and the Centers for Disease Control and Prevention (CDC). Visit http://www.vaers.hhs.gov or call 1-800-822-7967.

Please see full Prescribing Information for PENBRAYA and full Prescribing Information for TRUMENBA.Indications
  • PENBRAYA is indicated for active immunization to prevent invasive disease caused by Neisseria meningitidis serogroups A, B, C, W, and Y. PENBRAYA is approved for use in individuals 10 through 25 years of age
  • TRUMENBA is indicated for active immunization to prevent invasive disease caused by Neisseria meningitidis serogroup B. TRUMENBA is approved for use in individuals 10 through 25 years of age